,44,45Metastatic ovarian cancer cells abundantly secrete exosomes that express solubleE-cadherin, an angiogenesis inducer, and heterodimerize with VE-cadherin expressed onendothelial cells to activate β-catenin and NFКB signaling, suggesting that increasedexpression of soluble E-cadherin on exosomes of ovarian origin could serve as a diagnosticand prognostic biomarker for ovarian cancer.8 This evidence concerns the gene CDH5 and ovarian cancer.