To test the association between TERT, OGG1, and CHRNA5 gene polymorphisms and the risk of LC, we conducted a case-control study consisting of 144 NSCLC cases and 211 controls enrolled in four University Hospitals of Eastern Algeria (Constantine, Sétif, Batna, and Annaba). The gene discussed is CHRNA5; the disease is non-small cell lung carcinoma.