As expected, we found rs6784267 in the CCM3 gene interacted with rs3025010 in the VEGFA gene while both of our studies did not found associations between CCM3 gene polymorphism and hypertension, which is in line with our previous hypothesis that the CCM3 gene could affect blood pressure in a manner of interacting with other factors. The gene discussed is VEGFA; the disease is hypertensive disorder.