In parallel, oxidative stress impairs ERK pathway signaling by decreasing protein kinase C δ (PKCδ) phosphorylation and DNA methyltransferase 1 activity, thus directly leading to hypomethylated status of DNA observed in SLE and overexpression of genes associated with pathogenesis of SLE [23–29]. This evidence concerns the gene PRKCD and systemic lupus erythematosus.