The down-regulation of MACROD2 was correlated with tumor size (P = 0.021), tumor encapsulation (P = 0.005), vascular invasion (P = 0.020), tumor differentiation (P = 0.044), and tumor node metastasis (TNM) staging (P = 0.011) in the 380 patients with HCC in the FFPE cohort (Supplementary Table 6). This evidence concerns the gene MACROD2 and hepatocellular carcinoma.