Recent studies have shown that tumor cell-derived exosomes play a prominent role in the pathology of tumor metastases by using tumor-signaling pathway such as caveolin-1, HIF-1a, miR-21, miR-105, miR-210, β-catenin and oncogenic kinases (e.g., mutated EGFR, RAS and MAP kinases) [2,41,42,43,44]. This evidence concerns the gene HIF1A and neoplasm.