This in-depth review on the study of different epigenetic modifiers in the context of breast cancer metastasis led to the formulation of a panel of epigenetic factors namely APLF, HJURP, MacroH2A.1, ɣH2AX and H2Bub1, that could be exploited to detect the potential of breast cancer to become metastatic in nature. The gene discussed is APLF; the disease is breast cancer.