Further analysis of correlation between OTUB1 and clinic pathologic characteristics of RCC patients indicated that among the 67 patients, high expression of OTUB1 (N = 34) was significantly correlated with T stage (P = 0.007), N stage (P = 0.026) and M stage (P = 0.019) (Table 1). The gene discussed is OTUB1; the disease is renal cell carcinoma.