Ovarian tumor (OTU)-containing DUBs is one of the members of DUBs [9] and OTUB1 (ovarian tumor domain protease domain-containing ubiquitin aldehyde-binding proteins) is a member of OTU domain protease superfamily of DUBs that removes ubiquitin from branched polyubiquitin chains in the target molecules [10]. The gene discussed is OTUB1; the disease is ovarian neoplasm.