The experimentally estimated serum TRAb concentrations in patients with Graves’ disease ranged from 50 to 500 μg/L (TRAb range 1.5–110 U/L) while in patients with autoimmune hypothyroidism with TSHR blocking autoantibodies ranged from 1.7 to 27 mg/L (TRAb range 134–1290 U/L) [38]. This evidence concerns the gene TSHR and Graves disease.