A similar increase was observed in PBC patients for anti-PDC-E2 (mean 8.86%/year), anti-PDC-E2 avidity (mean 4.94%/year) and ELF score (mean 2.71%/year), with no significant difference regarding the temporal behavior of BN/AMA subjects (p = 0.527, p = 0.205 and p = 0.415, respectively). Here, PDC is linked to primary biliary cholangitis.