TIMP1 and Hepatic fibrosis: One particularly powerful non-invasive assessment of liver histology is the Enhanced Liver Fibrosis (ELF) score, an algorithm capable of estimating the degree of hepatic fibrosis based on the serum concentrations of the tissue inhibitor of metallo-proteinases-1 (TIMP-1), amino-terminal propeptide of type III procollagen (PIIINP) and hyaluronic acid (HA) [19].