In contrast, the incubation with LPS plus the IgG fractions from APS patients caused a significant increase (89.5 ± 6.7, p = 0.00001 for aβ2GpI and 86.8 ± 2.4, p = 0.00001 for aPS/PT, respectively) of TF mRNA expression, and no significant difference was observed between aβ2GpI+ and aPS/PT+ antibodies (Fig. 3). This evidence concerns the gene F2 and autoimmune polyendocrinopathy.