According to the 2006 revised international classification criteria, the presence of one among anti-beta2 glycoprotein I (aβ2GPI) IgG or IgM, anti-cardiolipin (aCL) IgG or IgM and the lupus anticoagulant (LAC) is required for a definite diagnosis of APS [1]. This evidence concerns the gene CD40LG and autoimmune polyendocrinopathy.