In contrast, treatment with LPS plus the IgG fractions isolated from APS patients, either expressing aβ2GpI, or aPS/PT antibodies, significantly up-regulated TF mRNA expression compared to LPS alone (10.2 ± 3.5 for aβ2GpI, p = 0.007 and 9 ± 1.1 for aPS/PT, p = 0.00001) and no significant difference was found between aβ2GpI and aPS/PT antibodies. Here, F2 is linked to autoimmune polyendocrinopathy.