SIAH1 and glioma: In gliomas, Deng et al., reported that PHF19 is up-regulated and promotes the proliferation and migration of glioblastoma cell lines through direct repression of the promoter of SIAH (seven in absentia homolog 1), an E3-ubiquitin ligase of β-catenin and thus activation of the Wnt/β-catenin pathway [45].