Whereas LNCaP cells which express AR and PSA are similar to prostate adenocarcinomas responsive to AR-depletion therapy, PC3 cells which do not express AR nor PSA but some neuroendocrine markers (NE) are characteristic of prostatic small cell neuroendocrine carcinomas (SCNC) which are aggressive tumors not responding to hormonal therapy [3]. This evidence concerns the gene AR and prostate small cell carcinoma.