Regarding the mechanisms, Sirtuin 1 (Sirt1) is regarded as a primary cardioprotective downstream modulator of RSV in both T1DM and T2DM states, contributing to antioxidation, antiapoptosis, and calcium hemostasis improvement by further regulating its downstream molecules in cardiomyocytes [23–25]. This evidence concerns the gene SIRT1 and type 2 diabetes mellitus.