SIRT1 and familial dilated cardiomyopathy: Regarding the role of Sirt3 in the cardioprotective effects of RSV against DCM injury, investigators have shown that RSV (25 mg/kg/day) significantly increases the expression and activity of both Sirt1 and Sirt3 and subsequently enhances mitochondrial function and biogenesis in diabetic myocardial tissues [68].