In terms of specific mechanisms, activated Sirt1 wash shown to increase the DNA-binding ability of forkhead box-O1 (FoxO1) at the promoter region of Rab7 and subsequently enhanced Rab7 expression, which contributed to the maturation of autophagosomes and their fusion with lysosomes, thus eventually causing autophagic flux improvement in the hearts with DCM [65, 81]. Here, FOXO1 is linked to familial dilated cardiomyopathy.