Domains of type V1 and C1 of RAGE bind a large variety of molecules (Figure 7), not only AGEs (endogenous or food-derived) but also advanced oxidation protein products (AOPPs), involved in oxidative stress [35], β-amyloid related to Alzheimer's disease [10, 74], calcium-binding S100 proteins linked to several human cancers [75], and high-mobility group box-1 (HMGB) expressed in cancer and inflammation [35, 76]. This evidence concerns the gene HMGB1 and cancer.