The active form of vitamin D is thought to be one of the main factors for the proliferation and development of vascular smooth muscle cells (VSMC), endothelial cells (EC), and immune system cells, which are the main cells in atherosclerosis and vascular elasticity.20 The Vitamin D receptor (VDR) present in these cells regulate VSMC relaxation and contraction by nitric oxide synthesis, and the calcium‐mediated pathways.20 Adverse effects of serum 25[D]D deficiency on VSMC and EC may contribute to syncope by causing deterioration of vascular function. The gene discussed is VDR; the disease is atherosclerosis.