P2RY12 and heart disorder: Many studies have shown that the five SNPs (rs9859538 G > A, rs1491974 A > G, rs7637803 C > T, rs6809699 A > C, and rs2046934 G > A) in the P2RY12 gene are associated with aspirin and clopidogrel resistance in heart disease and increases coronary artery aneurysm risk in Kawasaki disease.