This review suggests that:SARS-CoV S protein can downregulate ACE2Loss of pulmonary ACE2 function has been suggested to be associated with acute lung injury; the reduction in ACE2 function can cause dysfunction of the renin-angiotensin system [23] and enhance inflammation and vascular permeability.ACE2-associated lung injury has been suggested in SARS- CoV infectionFrom reading this article the following article was then discovered... The gene discussed is REN; the disease is injury.