IDH1 and acute myeloid leukemia: A first-in-class human phase Ib/II trial in patients with IDH1-mutated relapsed or refractory AML showed a CR/CRh rate of 30%, DOR of 8.2 months (95% CI 5.5–12), and median OS of 8.8 months (95% CI 6.7–10.2) [12].