Licochalcone A caused G2 and late-G1 arrests in androgen-independent PC-3 prostate cancer cells by affecting the expression of proliferating cell nuclear antigen (PCNA), DNA polymerase δ, Rb and E2F, cyclins B1 and D1, and so on, which led to apoptosis [42]. The gene discussed is PCNA; the disease is Familial prostate cancer.