The I-SPY 2 trial, an adaptive phase 2 trial, identifying eight biomarker subtypes with considering HER2 status, hormone receptor status, and risk based on a 70-gene profile, found that neratinib was more likely to have an increased pathological complete response (pCR) rate than trastuzumab when added to standard chemotherapy in patients with HER2-positive (HER2+) and hormone-receptor-negative (HR−) BC [18]. The gene discussed is NR4A1; the disease is breast cancer.