ERBB2 and skin disorder: Subgroup analysis of dual anti-HER2 regimen showed that the toxicities in the lapatinib group were mainly diarrhea, hepatic toxicity, and skin disorders, and the main toxicities for the neratinib group were diarrhea, nausea and vomiting, and fatigue, while for the pertuzumab group the main toxicity was diarrhea.