The results obtained in not-IR women are similar to those of De Cicco et al. They studied a group of obese PCOS women without IR treated with MI and ALA for six months, and they found an improvement of cycle length, BMI, hyperandrogenism, and ovarian volume without effects on HOMA-IR and AUC-insulin (both in a normal range at the baseline). The gene discussed is INS; the disease is hyperandrogenism.