Univariate analysis showed that some clinicopathologic features, including tumor location (left colon vs. rectum, HR = 1.302, P = 0.236; right colon vs. rectum, HR = 2.378, P < 0.001), differentiation degree (HR = 1.640, P = 0.004), tumor size (HR = 1.444, P = 0.022), T stage (HR = 4.296, P = 0.013), the number of metastatic lymph nodes (1-3 vs. 0, HR = 1.114, P = 0.641; ≥4 vs. 0, HR = 2.041, P = 0.001), M stage (HR = 4.677, P < 0.001), CEA level (HR = 3.787, P < 0.001), PNI status (HR = 1.692, P = 0.001), and TD count (HR = 1.641, P = 0.002), were significant prognostic factors for DSS. This evidence concerns the gene CEACAM5 and neoplasm.