Other research showed that 5-month (long-term) treadmill exercise in APP/PS1 transgenic mice was sufficient to inhibit AD-like neuropathology progression and improve hippocampal cognitive deficits by enhancing long-term potentiation (LTP), suppressing both Aβ-42 and neuronal death pathways, and inducing APP processing to reduce Aβ deposition [34, 35, 42]. Here, APP is linked to Alzheimer disease.