Using deep sequencing approaches, our group recently demonstrated that TRAV12-1 preferentially pairs with TCRβ variable region (TRBV) 2 in BAL CD4+ T cells from Löfgren's syndrome patients and that TRAV12-1 and TRBV2 are the most expanded variable regions relative to control subjects (81). Here, TRAV12-1 is linked to Löfgren’s syndrome.