Moreover, HXK2 is closely related to physiological process such as high glycolytic metabolism, cell proliferation, apoptosis, and autophagy in tumor cells, and the expression of HXK2 is significantly increased in cancer cells compared with normal cells, so the inhibition of HXK2 is an effective antitumor strategy (Vander Heiden et al., 2009; Wolf et al., 2011; Zhang et al., 2014). Here, HK2 is linked to cancer.