The present study showed that EMP treatment could affect the expression level of Atp2a2, and qPCR validation showed that EMP treatment could increase the expression level of Atp2a2. Furthermore, the upregulation of SERCA2 expression could increase insulin sensitivity and improve insulin resistance (25, 26), suggesting that the enhancement of insulin sensitivity of EMP may also related to the upregulated of Atp2a2. Here, INS is linked to Insulin resistance.