Therefore, our results suggested that EMP treatment could regulate the expression levels of genes in metal ion binding pathway that related to glucose and lipid metabolism (Klf10, Atp2a2, Cpped1, and Enpp2), β-cell function (Atp2a2 and Vav2) and cardiovascular homeostasis (Vav2), which may contribute to regulate glucose and lipid metabolism and prevent cardiovascular risk in T2D rats. Here, CPPED1 is linked to type 2 diabetes mellitus.