Genes in the negative regulation of transcription from the RNA polymerase II promoter pathway (Figure 5C) are involved in glucose metabolism (Sirt2), adipogenesis (Dact1and Gata2), β-cell function (Pik1 and Jund), and cardiovascular diseases (Sox17 and S100a1), et al. Among those genes, Sirt2 plays an important role in hepatic glucose uptake (34), and overexpression of Sirt2 in hepatic could improve glucose tolerance and increase insulin sensitivity (34, 35). Here, INS is linked to cardiovascular disorder.