Therefore, our results suggested that EMP treatment could regulate the expression levels of genes in metal ion binding pathway that related to glucose and lipid metabolism (Klf10, Atp2a2, Cpped1, and Enpp2), β-cell function (Atp2a2 and Vav2) and cardiovascular homeostasis (Vav2), which may contribute to regulate glucose and lipid metabolism and prevent cardiovascular risk in T2D rats. The gene discussed is ENPP2; the disease is type 2 diabetes mellitus.