TLX2 and intrahepatic cholangiocarcinoma: A role for NCX in pacemaker activity has been suggested in studies of interstitial cells of the urethra (Bradley et al., 2006; Drumm et al., 2015) and small intestine (Lowie et al., 2011), however, this hypothesis was not tested on ICC under conditions in which ENCX can be manipulated in single cells.