ANKRD1 and cardiomyopathy: The MARP family member CARP (Cardiac Ankyrin Repeat Protein) is particularity interesting considering, for example, the importance of CARP-regulated Nkx-2.5-dependent signaling pathways (Witt et al., 2004), that CARP interacts with the signaling molecule myopalladin (Bang et al., 2001), and that mutations in CARP that increase its binding affinity to titin have been linked to cardiomyopathy (Arimura et al., 2009).