AKT1 and neurodegenerative disease: Osthole (17) protects bone marrow-derived neural stem cells (BM-NSCs) from oxidative damage through the phosphatidylinositol 3 kinase (PI3K)/protein kinase B (Akt-1) pathway, and it has been shown to improve the inflammatory environment of neurodegenerative diseases and promote the survival rate of transplanted NSCs (Yan et al., 2017).