Bartter’s syndromes (BS) are a group of kidney genetic tubulopathies characterized by salt and fluid loss, elevated prostaglandin E2 (PGE2) production, increased renin and aldosterone circulating levels, normal-to-low blood pressure and growth delay (Simon et al., 1997; Birkenhäger et al., 2001; Andrini et al., 2015; Seys et al., 2017; Fulchiero and Seo-Mayer, 2019). The gene discussed is REN; the disease is Bloom syndrome.