However, the numbers of Iba-1-positive macrophages (pan-macrophages), CD204-positive macrophages (M2-like macrophages), CD3-positive lymphocytes, CD4-positive lymphocytes, and CD8-positive lymphocytes in subcutaneous tumor tissue remained unchanged following epimedokoreanin B administration (Figures 8A,B). The gene discussed is CD8A; the disease is neoplasm.