PEBP1 and acute kidney injury: While research using a mouse model of GPX4-induced acute renal failure showed that LOX15 is not required for ferroptosis (Friedmann Angeli et al., 2014), work on a variety of damaged cells shows that phosphatidylethanolamine binding protein 1 (PEBP1) forms a complex with ALOX15 and acts as a scaffold protein to positively regulate ferroptosis by (Wenzel et al., 2017).