The reduction in the levels of the cytoprotective ADP (Hotta et al., 2000; Tsochatzis et al., 2009) and Nrf-2 (Chowdhry et al., 2010; Shin et al., 2013) also contributes to the progression to the liver fibrosis stage (Contos et al., 2004). The gene discussed is NFE2L2; the disease is Hepatic fibrosis.