However, the overexpression of SSAT is described as a cyclooxygenase-independent effect, as shown for sulindac, acetylsalicylic acid, celecoxib, ibuprofen, and naproxen in several models of cancer (Babbar et al., 2003; Babbar et al., 2006a; Wood et al., 2011; Hughes et al., 2012; Xie et al., 2012). The gene discussed is SAT1; the disease is cancer.