PGP and status epilepticus: On the other hand, we also demonstrated that repetitive seizures and/or status epilepticus induce high expression of P-gp in neurons, astrocytes, and vessels, associated with the MDR phenotype (Lazarowski et al., 2004b; Höcht et al., 2007; Auzmendi et al., 2013; Merelli et al., 2019).