MAPT and Alzheimer disease: Since tau hyperphosphorylation is the main mechanism responsible for NFT formation, it has been suggested that inhibiting different tau kinases such as CDK5 and GSK3β, involved in tau hyperphosphorylation, could reduce their aggregation (Xie et al., 2017; Holzer et al., 2018), observed in AD (Morris et al., 2011) and epilepsy (Sen et al., 2007; Thom et al., 2011; Tai et al., 2016).