SCARB2 and Parkinson disease: Of note, the endosomal trafficking of LIMP2, a cargo of AP-3 complex, may be particularly important in relation to the pathomechanism of PD, given that LIMP2 is selectively responsible for the intracellular transport of a lysosomal enzyme β-glucocerebrosidase (βGC), a major risk factor for developing PD, to lysosomes through direct binding (Reczek et al., 2007; Saftig and Klumperman, 2009), and that LIMP2 deficiency in mice leads to α-synuclein accumulation as well as the reduction of lysosomal βGC activity (Rothaug et al., 2014).