In addition to macroautophagy, LRRK2 has been shown to be associated with the chaperon-mediated autophagy (CMA); whereas LRRK2 serves as a substrate of CMA, binding of PD-associated mutant LRRK2 with lysosomes in the presence of other CMA substrates adversely results in a defective CMA (Orenstein et al., 2013). The gene discussed is LRRK2; the disease is Parkinson disease.