It has been reported that, in the brains of patients with PD or dementia with Lewy bodies, LRRK2 is abnormally localized to the enlarged granules or vacuoles that correspond to the endolysosomal compartment (Higashi et al., 2009), although the specificity of the antibodies employed in this study has not been fully validated. Here, LRRK2 is linked to Parkinson disease.