Importantly, a majority of familial PD patients harboring LRRK2 mutation display an accumulation of Lewy bodies in affected brain lesions, although a range of heterogeneity (i.e., some cases are Lewy body predominant, while others exhibit tau deposits or lack specific intraneuronal inclusions) characterizes the neuropathology of LRRK2 mutant PD (Khan et al., 2005; Kalia et al., 2015). The gene discussed is MAPT; the disease is Parkinson disease.