LRRK2 and systemic lupus erythematosus: The action of LRRK2 may also cover the adaptive immunity, because antigen presentation by macrophages or dendritic cells is mediated at least in part by the lysosome-related organelle called MHC class II compartment (MIIC), and LRRK2 has been identified as a risk gene for systemic lupus erythematosus (SLE), a representative autoimmune disorder (Zhang et al., 2017).