For instance, the lysosomal enzyme glucocerebrosidase (GBA) and the lysosomal K+ channel TMEM175 are well-validated risk factors identified by GWAS of sporadic PD (Nalls et al., 2014; Chang et al., 2017; Blauwendraat et al., 2019; Iwaki et al., 2019). The gene discussed is GBA1; the disease is Parkinson disease.