Thus, FHL2 participates in various protein complexes regulating cell growth, differentiation and cytoskeletal remodeling as reported in immune cells and in the pathogenesis of numerous cancers (Canault et al., 2006; Wixler et al., 2007; Li et al., 2008; Qian et al., 2009; Kurakula et al., 2014). The gene discussed is FHL2; the disease is cancer.