However, urine cytology, urine tests like bladder tumor antigen (BTA) and nuclear matrix protein-22 (NMP-22), and newer molecular and genetic markers that detect gene mutations such as RAS, FGFR3, PIK3CA, and TP53 in urinary sediment may help in the early detection and prediction of urothelial carcinomas (van Rhijn et al., 2005[29]). The gene discussed is NUMA1; the disease is urothelial carcinoma.