On the other hand, high potential of the Hp2-2 in angiogenesis (Langlois and Delonghe, 1996[17]; Cid et al., 1993[9]) can pave the way for tumorigenesis and cancer progression (Rajabi and Mousa, 2017[25]; Mohajeri et al., 2017[22]). Here, ARL6IP5 is linked to cancer.