As shown in Fig. 7, the expression levels of CA2, CHP2, SULT1B1, MOGAT2 and C1orf115 were significantly decreased in CRC cell lines compared with NCM460 (P < 0.001), which were consistent with the results of differential expression analysis, suggesting that the results were convincing (Fig. 7a–e). This evidence concerns the gene C1orf115 and colorectal carcinoma.