The 4 key genes consist of ALOX5AP, HLA-DMB, HLA-DRA and SPINT2. ALOX5AP, also called 5-LO-activating protein (FLAP), which plays an important role in synthesis of leukotriene and associates with prognosis of primary neuroblastoma patients and esophageal squamous cell carcinoma patients [28]. This evidence concerns the gene SPINT2 and esophageal squamous cell carcinoma.