In the past, most studies have focused on intracellular TLRs such as TLR3, TLR7, and TLR9, but recent studies have shown that cell-surface TLRs, particularly TLR2, also play an important role in the development of autoimmune diseases, and TLR2 expression is not limited to cells related to inflammation and immune function [12]. This evidence concerns the gene TLR2 and autoimmune disease.