TNFα is not only a proinflammatory cytokine and participates in obesity-related systemic insulin resistance by inhibiting tyrosine kinase of the insulin receptor in muscle and fat but also known to be indispensable for follicular formation, oocyte maturation, and androgen synthesis and to mediate insulin resistance [26]. The gene discussed is TNF; the disease is obesity due to melanocortin 4 receptor deficiency.