RDH8 and retinal degeneration: Other compounds including retinylamine [36, 53], C20-d3-vitamin A, [54], Emixustat [55], primary amines [56], omega-3 fatty acids [57] and the selective oestrogen receptor modulator raloxifene [47], among others, have been shown to reduce A2E accumulation and concomitantly to “rescue” retinal degeneration in Abca4-/- Rdh8-/- mice or Abca4-/-in vivo.