In the present study, we tested on one hand, the effect of four intraperitoneal injections of 10 mg/kg of norbixin administered before and during the course of a modified BLD exposure in BALB/c mice, an acute model used to rapidly study the neurodegeneration symptomatic of AMD, and, on the other hand, the effect of norbixin supplementation for 5 to 6 months in Abca4-/- Rdh8-/- mice of different ages, a chronic model of AMD and STGD. Here, RDH8 is linked to age-related macular degeneration.