CRB1 and retinal degeneration: It is noteworthy that despite the fact that the mice we used also carried the rd8 mutation in the Crb1 gene, we haven’t observed the formation of photoreceptor “rosettes” in the retina nor focal inferior retinal degeneration characterized by the formation of local retinal folds representative of rd8-/- mouse retinal phenotype [44] (data not shown).