PVs were identified in 25/177 (14.1%) cases of the referred, unrelated PDAC cohort affecting ten different genes: ATM (6.8%, N = 12, including two ATM cases that each had a PV in a second cancer susceptibility gene (ATM/BRCA2 and ATM/SDHA)); BRCA2 (2.3%, N = 4, including the aforementioned case with a second PV in ATM); CDKN2A (1.1%, N = 2); MSH2 (1.1%, N = 2); CHEK2 (1.1%, N = 2); SDHA (0.6%, N = 1, the case with a second PV in ATM); BRIP1 (0.6%, N = 1); monoallelic MUTYH (0.6%, N = 1); MITF (0.6%, N = 1); and NBN (0.6%, N = 1) (Table S2). This evidence concerns the gene MSH2 and cancer.