We found PV in known PDAC susceptibility genes in 19/177 patients (10.7%) overall with cascade screening implications that can alter management of healthy at‐risk relatives (ATM (10), ATM/SDHA (1), BRCA2 (3), BRCA2/ATM (1), CDKN2A (2), and MSH2 (2)). The gene discussed is MSH2; the disease is acquired polycythemia vera.