WM alterations have also been examined in several types of transgenic mice carrying the APP/PS1 (K670N/M671L Swedish and PS1dE9) mutation, PS1 mutation, and 5xFAD mutation (Swedish mutation, 1716V Florida mutation, V717I London mutation, and PS1 with M146L and L286V mutation), as well as 3xTg‐AD mice (APP Swedish mutation, a presenilin knock‐in mutation and P301L tau) [111, 112, 113, 114, 115, 116, 117]. This evidence concerns the gene MAPT and Alzheimer disease.