Regarding myelin proteins, progressive reduction in the levels of myelin basic protein (MBP), myelin proteolipid protein (PLP) and 2′,3′‐cyclic nucleotide 3′‐phosphodiesterase (CNP) has been reported in the WM of the parietal and occipital lobes in AD correlating with Braak stages V–VI [90]. Here, PLP1 is linked to Alzheimer disease.