Conceptualization, Formal analysis, Validation, Investigation, Methodology, Writing - review and editing, sample preparation for phosphoproteomic analysis; data interpretation; in situ metabolic labeling and isoelectrofocusing analysis; expression, purification and enzymatic analysis of IMPDH1 phosphomimetic and phosphoknockout mutants; in vitro phosphorylation assays of phosphoknockout and blindness mutants; data analysis of HPLC nucleotide determinations; data analysis of ERG recordings; generation of IMPDH1 antibody and immunolocalization assays. This evidence concerns the gene IMPDH1 and Blindness.