Previous studies have shown that the expression of AQP1 is positively associated with invasion, angiogenesis, cell migration, and the formation of edema in malignant tumors,7, 8, 9, 10, 11 and high‐grade astrocytomas express higher levels of AQP1 than low‐grade astrocytomas.12 This evidence concerns the gene AQP1 and astrocytoma (excluding glioblastoma).