Furthermore, Boudot and his colleagues found that in estrogen receptor (ER) positive breast cancer, estradiol can promote the growth of ER positive breast cancer cells by producing a large number of CXCL12 and regulating CXCR4 and CXCR7 receptors of CXCL12, and the chemokine receptor CXCR4 can enhance the response of cells to estradiol.30 The gene discussed is ESR1; the disease is breast cancer.