In the study of the relationship between tamoxifen resistance and cancer‐associated fibroblasts, it was found that after TAM treatment, the secretion of CXCL16 increased under the guidance of G‐protein coupled receptor 30, and the exocrine CXCL16 promoted the migration and invasion of MCF‐7 cells.81 The gene discussed is CXCL16; the disease is cancer.