NLRP6 and viral infectious disease: The host dominant resistance (R) gene, which codes a protein that recognizes virus avirulence protein (Avr), can trigger hypersensitive response upon virus infection and/or extreme resistance (ER) either through direct or indirect interactions with Avr, which can lead to, systemic resistance for the host against the virus (Bonas et al. 2002; Goldbach et al. 2003; Soosaar et al. 2005).